Genetic variation in immune response is probably involved in the
progression of sepsis and mortality in septic patients. However,
findings in the literature are sometimes conflicting or their
significance is uncertain. Thus, we investigated the possible
association between 12 polymorphisms located in the interleukin-6
(IL6), IL10, TLR-2, Toll-like receptor-4 (TLR-4), tumor necrosis
factor-α and tumor necrosis factor-β (lymphotoxin α -
LTA) genes and sepsis. Critically ill patients classified with sepsis,
severe sepsis and septic shock and 207 healthy volunteers were analyzed
and genotyped. Seven of the nine polymorphisms showed similar
distributions in allele frequencies between patients and controls.
Interestingly, our data suggest that the IL10-819 and TLR-2
polymorphisms may be potential predictors of sepsis.