Medknow Publications on behalf of the Neurological Society of India
Abstract
Stiff limb syndrome (SLS) is a rare "focal" variant of stiff person
syndrome which presents with rigidity and painful spasms of a distal
limb, and abnormal fixed foot or hand postures. Anti-glutamic acid
decarboxylase antibodies (GAD-Ab) are variably present in most cases.
Most reported cases of SLS are unassociated with cancer. We describe a
patient with SLS as a paraneoplastic manifestation of breast carcinoma,
in whom GAD-Ab was present. The patient responded very well to oral
diazepam, baclofen and steroids.This is the third reported case of SLS
as a paraneoplastic accompaniment to cancer