Medknow Publications on behalf of the Neurological Society of India
Abstract
Background : Delayed cerebral ischemia from cerebral arterial vasospasm
following aneurysmal subarachnoid hemorrhage (aSAH) is associated with
significant morbidity and mortality. Early recognition of the cerebral
arterial vasospasm and institution of appropriate treatment can reduce
the consequences. Aim : We investigated the association of transcranial
Doppler (TCD) and Xe-CT with the characteristics of symptomatic
vasospasm secondary to aneurysmal subarachnoid hemorrhage (SAH) in
patients who underwent euvolemic treatment without sedation. Materials
and Methods : Data collected prospectively in patients with aSAH
admitted to a neurocritical care unit in a regional hospital were
retrospectively analyzed. Out of the 98 consecutive patients with aSAH,
30 patients underwent paired Xe-CT (not sedated) and TCD studies.
Correlation between cortical cerebral blood flow (CBF) and mean blood
flow velocity in middle cerebral artery (MCA) territories was analyzed.
The lowest cortical regional CBF and MCA velocity were compared between
patients with and without symptomatic vasospasm. Results : Symptomatic
vasospasm occurred in 12 patients. No correlation was found between CBF
and mean blood flow velocity of the MCA territory. The differences
between MCA velocity and lowest cortical CBF in patients with
symptomatic vasospasm were significantly different from patients
without symptoms. Conclusion : TCD does not help to predict regional
CBF in the MCA territory in patients with aSAH on euvolemic treatment