Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
Abstract
Background : Although a wide number of experimental evidences are
available regarding oxidant-antioxidant disturbance in hypertension,
clinical data supporting it is lacking in men in early stages of
hypertension. Aims: The objective of the study was to evaluate
oxidative status and antioxidant activities in males with stage I
essential hypertension. Materials and Methods : Thirty hypertensives
and 21 normotensives were included in the study. Protein carbonyl,
reduced glutathione, glutathione peroxidase, catalase and fasting
glucose were assessed in both the groups. Statistical Analysis :
Results were analyzed by student′s ′t′ test and
linear regression analysis test. Results : Plasma protein carbonyl and
glutathione peroxidase were significantly increased, and catalase and
GSH were significantly reduced in the hypertensive group compared to
normotensive subjects. There was a significant negative correlation
between glutathione peroxidase and catalase in the test group.
Conclusions : The data from the present study indicates an alteration
in oxidant-antioxidant status in non-obese men in early stages of
essential hypertension