The present study is a fourteen day study, designed to investigate the
hematological and biochemical effects of single, daily oral doses of
100 – 600 mg/kg of a Nigerian Polyherbal Tonic Tea (PHT) in four
groups of adult Wistar rats. Acute oral toxicity test of PHT at the
limit dose of 5000 mg/kg was also conducted using Up-and-Down Procedure
on statistical software program (AOT425StatPgm, Version 1.0.). Results
showed PHT to induce significant (p<0.05) dose-related elevation in
the packed cell volume (PCV), platelet, total leukocyte counts and
lymphocyte differentials, while causing significant (p<0.05)
suppression of granulocyte differentials in dose-related fashion. PHT,
also, induced a significant (p<0.05) dose-dependent rise in the
fasting blood sugar which was at variance with its folkloric use as an
oral hypoglycemic agent. PHT did not induce mortality at the tested
limit oral dose, indicating its relative oral safety up to 5000 mg/kg
on acute exposure
