Aim: Neurotoxicity is the next common side effect of cisplatin
(CDDP)-based chemotherapeutics following nephrotoxicity. We
investigated the effect of CDDP on some brain metabolic enzyme
activities such as hexokinase (HK), glucose-6-phosphate dehydrogenase
(G6PD), lactate dehydrogenase (LDH), and malate dehydrogenase (MDH) in
an experimental model of CDDP toxicity, and examined the protective
role of Caffeic acid phenethyl ester (CAPE), a phenolic antioxidant
derived from the honeybee propolis, on the enzyme activities mentioned
above. Methods: Female Wistar albino rats were divided into three
groups: sham operation group (n:6), CDDP group (n:9), and CAPE + CDDP
group (n:8). All the chemicals used were applied intraperitoneally. HK,
G6PD, LDH, and MDH activities were determined spectrophotometrically in
the brain supernatant at the end of the surgical procedures. Results:
There were decreased G6PD activities and increased MDH activities in
CDDP group compared to control group (p<0.05, p<0.05). LDH
activities were increased in CAPE+CDDP group compared to CDDP group
(p<0.001). Conclusion: These results provide a new point of view on
the glucose metabolizing enzymes of brain tissue affected from CDDP and
the protective effects of CAPE on these enzymes
