Medknow Publications on behalf of Indian Cancer Society
Abstract
Background: The allele frequency of the multidrug resistance 1 (MDR1)
gene C3435T polymorphism differs with different ethnic populations,
such as Asian, African, and Caucasian. This polymorphism has been
reported to be associated with the increase of gastric cancer.
Objectives: The objective of this study was to find out the association
of gastric cancer incidence with MDR1 gene polymorphism in an ethnic
Iranian population. Materials and Methods: In this study, 48 gastric
cancer patients were diagnosed. Genomic DNA was extracted by a
salting-out method. The MDR1 polymorphism was studied by a polymerase
chain reaction (PCR)-restriction fragment length polymorphism method,
using a standard method. Results: The polymorphic homozygote (T/T)
genotype showed significantly an association with the incidence of
gastric cancer compared with controls (P < 0.05). Conclusions: This
study suggests that C3435T polymorphism of the MDR1 gene may be
associated with gastric cancer in an ethnic Iranian population