Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
Abstract
The chloroform extract of Andrographis paniculata roots was tested for
its antihyperglycemic activity in alloxan induced diabetic rats using
chronic and acute studies. The blood glucose lowering activity was
determined after oral administration at doses of 50, 100 and 150 mg/kg
body weight in acute study. Where as in case of chronic study blood
glucose, protein, albumin and creatinine levels were estimated after 4
weeks of treatment at the dose of 300 mg/kg. Significant reductions in
blood glucose levels were observed in both acute and chronic studies.
The extract significanly inhibited the induction of albuminuria,
proteinemia and uremia. The present study clearly indicated a
significant antidiabetic activity with the chloroform extract of A.
paniculata roots and supports the traditional usage of the plant by
Ayurvedic physicians for the control of diabetes. Also the extract is
useful in preventing the incidence of long-term complication, diabetic
nephropathy