Razi Institute for Drug Research (RIDR) of Iran University of Medical Sciences and Health Services (IUMS)
Abstract
Triphala' is an age old commonly used Ayurvedic powdered preparation in
Indian systems of medicine. This well known formulation is made by
combining Terminalia chebula, Terminalia belarica and Emblica
officinalis, in equal proportions based on the observation of Ayurvedic
Formulary of India (AFI). The formulation is prescribed in the first
line treatment of many aliments and is used as laxative, detoxifying
agent and rejuvenator. To establish its clinical validity the present
work was undertaken to evaluate its therapeutic potentials and adverse
effects. The Triphala formulation was standardized by HPTLC (High
Performance Thin Layer Chromatography), using Gallic acid as a marker
and was subjected to clinical studies. After proper screening 160
patients of age between 16–52 years were selected for 45 days
clinical study. The effectiveness of trial drugs were judged on the
basis of the subjective and objective parameters. It was observed that
the amount, frequency and consistency of stool were improved in
Triphala treated group. The changes of odor, mucous, flatulence,
belching and abdominal pain where also taken into account. The well
being was assessed on the basis of the parameters like concentration,
appetite, thirst, sleep, hyperacidity in arbitrary scoring system.
Triphala was found to have good laxative property, help in management
of hyperacidity and also improve appetite. No adverse effect was
observed in the treated group when compared to normal patients.
Triphala can be used effectively in the treatment of constipation and
other gastric problems