Medknow Publications and Staff Society of Seth GS Medical College and KEM Hospital, Mumbai, India
Abstract
AIMS: To additionally purify and characterise the anti-RNA
virus-directed protein termed p14. MATERIALS AND METHODS: Antiviral
assays of p14 against RNA and DNA viruses were carried out and its
antigenic similarities with chicken interferon (CIFN) were studied.
HPLC-Reverse Phase of p14 was performed to further purify p14. RESULTS:
p14 showed antiviral activity against RNA viruses only and not against
DNA viruses. It was antigenically distinct from CIFN. Purification of
p14 yielded three proteins with antiviral activity, which had different
physico-chemical properties than those described for interferons.
CONCLUSIONS: The data presented on the antiviral, immunological and
physico-chemical properties, establish the unique nature of p14
vis-à-vis those of interferons
