Medknow Publications on behalf of Indian Journal of Medical Sciences Trust
Abstract
Background: Although experimental studies have demonstrated that
reduced glutathione (GSH) is involved in cellular protection from
deleterious effects of oxygen free radicals in ischaemia and
reperfusion, there are controversial data on the correlation between
levels of GSH and the ischaemic process. Aim: The present study was
planned to evaluate erythrocyte GSH levels in patients with acute
myocardial infarction (AMI). Setting & Design: Erythrocyte GSH
levels were determined in 22 patients with AMI and 15 age matched
healthy volunteers served as control. Material & Methods:
Erythrocyte GSH levels were measured by using Bentler in AMI and
control patients. Also lipid profile was analyzed enzymatically in
these subject. Statistics: The values were expressed as means ±
standard deviation (SD) and data from patients and controls was
compared using student's 't'-test. Results & Conclusion: GSH levels
were significantly decreased in AMI as compared to control
(p<0.001). Also, total cholesterol and triglycerides were higher is
AMI subjects (p<0.05). These finding suggest that depressed GSH
levels may be associated with enhanced protective mechanism to
oxidative stress in AMI
