Medknow Publications on behalf of Indian Pharmacological Society
Abstract
Objective: To investigate the effect of azoles viz metronidazole
(MTZ), tinidazole (TNZ), ketoconazole (KCZ), and fluconazole (FLZ) on
resutured incision, excision, and dead space wounds in albino rats.
Materials and methods: Resutured incision, excision, and dead space
wounds were inflicted in albino rats of either sex under light ether
anesthesia, taking aseptic precautions. Control animals received
vehicle, and other groups received MTZ, TNZ, KCZ, and FLZ orally for a
period of 10 days in incision and dead space wounds, whereas in
excision wounds till their complete closure. On the 11th day, after
estimating breaking strength of resutured incision wounds (under
anesthesia), animals were sacrificed and granulation tissue removed
from dead space wounds to estimate breaking strength, hydroxyproline
content, quantification of granulation tissue, and histological studies
in control and treated groups. In the excision wound model, wound
closure rate, epithelization time, and scar features were studied from
the day of wounding till the day of scab falling off with no residual
raw area. Results: Except ketoconazole, rest of the azoles
significantly (P<0.01, <0.05) promoted the healing process in all
the three wound models studied. Conclusion: Metronidazole, tinidazole
and fluconazole promote wound healing, whereas ketoconazole does not do
so
