Effects of different preparations of Soybean diet on histamine or
carbachol-induced acid secretion and indomethacin –induced
ulceration were studied in male albino Wister rats. The animals were
divided into four dietary groups (groups I, II, III and IV) and fed
normal rat diet, 75% soybean diet, 50% soybean diet and 25% soybean
diet respectively. Rats in group I served as control. After six weeks
of feeding, acid secretion studies using histamine (3mg/Kg) or
carbachol (50μg/Kg) and ulcer studies were carried out. While
histamine and carbachol produced 400% and 350% increases respectively
in acid output in rats fed normal diet, the acid output in soybean diet
fed rats were between 210% and 280%. Also, rats fed soybean diets had
lower ulcer scores than rats fed normal diet. Indeed, the higher the
concentration of soybean in the diet the lesser the ulcer scores. The
results therefore seem to suggest that soybean has buffering effect on
induced acid secretion and protect the stomach against ulcer formation
