Gambian trypanosomosis (Sleeping Sickness) is a complex and
debilitating disease of man. For many years the disease has been
ravaging in several parts of sub-saharan Africa despite decades of
therapeutic control. Although animal reservoir hosts are believed to be
associated with the disease, not much evidences have been established
to prove the true existence of animal reservoir hosts for Trypanosoma
brucei gambiense and the zoonotic nature of Gambian Sleeping
Sickness. This paper reviews recent evidences based on molecular and
other biotechnologies leading to the identification of mammalian hosts
as reservoirs of T. b. gambiense and the roles of such hosts in
transmission and resurgence of sleeping sickness in sub-Saharan Africa
