More than 100 million Americans are currently living with at least one chronic health condition and expenditures on chronic diseases account for more than 75 percent of the $2.3 trillion cost of our healthcare system. To improve chronic illness care, patients must be empowered and engaged in health self-management. However, only half of all patients with chronic illness comply with treatment regimen. The self-regulation model, while seemingly valuable, needs practical tools to help patients adopt this self-centered approach for long-term care. \par In this position paper, we propose Mobile-phone based Patient Compliance System (MPCS) that can reduce the time-consuming and error-prone processes of existing self-regulation practice to facilitate self-reporting, non-compliance detection, and compliance reminders. The novelty of this work is to apply social-behavior theories to engineer the MPCS to positively influence patients\u27 compliance behaviors, including mobile-delivered contextual reminders based on association theory; mobile-triggered questionnaires based on self-perception theory; and mobile-enabled social interactions based on social-construction theory. We discuss the architecture and the research challenges to realize the proposed MPCS
