Matching the performance of autografts with engineered scaffolds remains a challenge in peripheral nerve repair. A combination of 3D biomimetic architecture interspersed with 2D surfaces has been hypothesized to be an ideal environment for neurite regeneration. However, the problem of how best to arrange material within a conduit is an open one. Optimizing material parameters such as density, cross-sectional geometry and spatial distribution would require an extensive programme of experimental testing. By contrast, developing a modelling framework that is capable of testing key parameters may accelerate the design process, and reduce the dependency on animal testing
