Inhibition of matrix metalloproteinase-9 (MMP-9) activity by cleistanthin A, a diphyllin glycoside from Cleistanthus collinus

Abstract

Matrix metalloproteinases (MMPs) are responsible for the remodeling of the extracellular matrix throughout the body. Inhibitors of these enzymes have been suggested as potential therapeutic agents for use in treatment of cancer. Our observations showed that cleistanthin A, a diphyllin glycoside from the leaves of the plant Cleistanthus collinus inhibited MMP-9, a 92 kDa matrix metalloproteinase. Further evaluation of this compound might reveal many such novel properties that might help in the evolution of this compound as an anticancer drug