Halasa, Tariq

Sørensen, Anna Irene Vedel

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Copenhagen University Research Information System

u n i ve r s i t y  o f  co pe n h ag e n  Københavns UniversitetReducing load of LA-MRSA on a pig farmSørensen, Anna Irene Vedel; Halasa, TariqPublication date:2019Citation for published version (APA):Sørensen, A. I. V., & Halasa, T. (2019). Reducing load of LA-MRSA on a pig farm: a simulation study. Postersession presented at SVEPM 2019, Utrecht, Netherlands.Download date: 01. Feb. 2020Reducing load of LA-MRSA on a pig farm – a simulation studyBackground• Livestock-associated Methicillin-resistant Staphylococcus aureus (LA-MRSA) is an opportunitic human pathogen• It is widespread in the Danish pig population, where 88% of a randomsample of pig production farms weretested positive in 2016• At present there is a lack of succesful intervention strategies against LA-MRSA other than completedepopulation of the farmsAnna Irene Vedel Sørensen & Tariq HalasaUNIVERSITY OF COPENHAGEN DEPARTMENT OF VETERINARY AND ANIMAL SCIENCESReferences• Broens et al. Longitudinal study on transmission of MRSA CC398 within pig herds. BMC Vet Res. 2012;8: 58.• Sørensen al. A mechanistic model for spread of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA ) within a pig herd. PLoS One. 2017;12: e0188429. Corresponding author:Anna Irene Vedel SørensenPostdocEmail: anvso@sund.ku.dkUniversity of CopenhagenFaculty of Health and Medical SciencesDepartment of Veterinary and Animal SciencesSection for Animal Welfare and Disease ControlGrønnegårdsvej 81870 Frederiksberg C DenmarkLA-MRSALA-MRSAMain idea• Reducing the load of LA-MRSA in the barn air → reduced LA-MRSA exposure for those entering the pig barns• It is the hope that this will lead to lessspread of LA-MRSA into the general population, which includes more vulnerable individualsLoad ↓Figure 1: Mean, median , min. and max. level of LA-MRSA in barn air, when use of risk anticirobials are terminated 180 days after LA-MRSA was introducedStop for use of risk antibioticsFigure 2: The effect of single interventions reducing the load on the prevalence of LA-MRSA positive pigs in the five stable unitsPreliminary results• The level of LA-MRSA in the air, and therebyhuman exposure seems to vary considerablybetween rooms and over time (Fig. 1)• After implementing single interventions that led to one- or two-log reductions in the nasal load carried by the pigs,  the prevalence of LA-MRSA positive pigs will quickly again reach the levelprior to intervention (Fig. 2). A continuous effortseem to be required (Fig. 3)• A word of caution: At present, we have noknowledge of the true impact of load on the ability of pigs to spread LA-MRSA to other pigs. Therefore, the weighting of the different load classes orginate from calibration to the original model (without load), which was parameterisedusing transmission rates from a longitudinalstudy (Broens et al, 2012)                                                                       Materials and methods• This model is an extension of a  mechanistic model, described in Sørensen et al, 2017• Load has been semi-quantitativelyinluded in the form of five different load classes• The parameterisation of load in pigs and air  was based on data from Hansen et al and Bækbo et al (bothunpublished)Figure 3: The effect of continuous interventions, which reduce the load by one load class in a gradually larger proportion of the pigs

Reducing load of LA-MRSA on a pig farm:a simulation study

https://curis.ku.dk/ws/files/231906523/Poster_Sorensen.pdf

Reducing load of LA-MRSA on a pig farm:a simulation study

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