Il rinnovato interesse per l'esplorazione dello spazio ha evidenziato la necessità di una comprensione profonda dei rischi per l'equipaggio e delle opportunità commerciali insite nel volo, sia in bassa orbita terrestre che nello spazio profondo. L'esplorazione spaziale rappresenta una sfida complessa per gli organismi di origine terrestre, comportando per essi notevoli stress di natura fisica (transizioni gravitazionali, permanenza in microgravità ed assorbimento di radiazioni cosmiche), ma anche chimica, microbiologica e psicologica. Fortemente ostile alla vita, l'ambiente spaziale rappresenta inoltre un prezioso banco di prova di strumenti innovativi per il contrasto di numerosi fenomeni degenerativi associati all'invecchiamento, nonché all'insorgenza di malattie a Terra. Fra questi strumenti, quelli nanotecnologici iniziano a mostrare evidenze promettenti di un valido supporto alla vita nello spazio

de Koning, Elisa J.

El Hilali, Jamila

Lips, Paul

Sohl, Evelien

van Ballegooijen, Adriana J.

van Marwijk, Harm W J

van Schoor, Natasja M.

Visser, Marjolein

Italian

Observational studies suggest that low concentrations of serum 25-hydroxyvitamin D (25(OH)D) and high concentrations of parathyroid hormone (PTH) are associated with a higher risk of mortality. The aim of this study was to examine whether 25(OH)D and PTH concentrations are independently associated with overall and disease-specific (cardiovascular and cancer-related) mortality in a large, prospective population-based cohort of older adults. Data from 1317 men and women (65-85 years) of the Longitudinal Aging Study Amsterdam were used. Cox proportional hazard analyses were used to examine whether 25(OH)D and PTH at baseline were associated with overall mortality (with a follow-up of 18 years) and disease-specific mortality (with a follow-up of 13 years). Compared to persons in the reference category of ≥75nmol/L, persons with serum 25(OH)D &lt;25nmol/L (HR 1.46; 95% CI: 1.12-1.91) and 25-49.9nmol/L (HR 1.24; 95% CI: 1.01-1.53) had a significantly higher risk of overall mortality, as well as men with baseline PTH concentrations ≥7pmol/L (HR 2.54 (95% CI: 1.58-4.08)), compared to the reference category of &lt;2.33pmol/L. The relationship of 25(OH)D with overall mortality was partly mediated by PTH. Furthermore, men with PTH concentrations of ≥7pmol/L (HR 3.22; 95% CI: 1.40-7.42) had a higher risk of cardiovascular mortality, compared to the reference category. No significant associations of 25(OH)D or PTH with cancer-related mortality were observed. Both 25(OH)D and PTH should be considered as important health markers.</p

de Koning, Elisa J

van Ballegooijen, Adriana J

van Schoor, Natasja M

VU Research Portal

Vitamin D, PTH and the risk of overall and disease-specific mortality:Results of the Longitudinal Aging Study Amsterdam

Genchi, Giada Graziana

Ciofani, Gianni

ESE - Salento University Publishing

Le nuove frontiere del volo spaziale: Nanotecnologie e Biomedicina

Observational studies suggest that low concentrations of serum 25-hydroxyvitamin D (25(OH)D) and high concentrations of parathyroid hormone (PTH) are associated with a higher risk of mortality. The aim of this study was to examine whether 25(OH)D and PTH concentrations are independently associated with overall and disease-specific (cardiovascular and cancer-related) mortality in a large, prospective population-based cohort of older adults. Data from 1317 men and women (65-85 years) of the Longitudinal Aging Study Amsterdam were used. Cox proportional hazard analyses were used to examine whether 25(OH)D and PTH at baseline were associated with overall mortality (with a follow-up of 18 years) and disease-specific mortality (with a follow-up of 13 years).Compared to persons in the reference category of ≥75. nmol/L, persons with serum 25(OH)D </p

The University of Manchester - Institutional Repository

Jamila El Hilali

Elisa J. de Koning

Adriana J. van Ballegooijen

Paul Lips

Evelien Sohl

Harm W.J. van Marwijk

Marjolein Visser

Natasja M. van Schoor

Crossref

The Journal of Steroid Biochemistry and Molecular Biology

Vitamin D, PTH and the risk of overall and disease-specific mortality: Results of the Longitudinal Aging Study Amsterdam

Observational studies suggest that low concentrations of serum 25-hydroxyvitamin D (25(OH)D) and high concentrations of parathyroid hormone (PTH) are associated with a higher risk of mortality. The aim of this study was to examine whether 25(OH)D and PTH concentrations are independently associated with overall and disease-specific (cardiovascular and cancer-related) mortality in a large, prospective population-based cohort of older adults. Data from 1317 men and women (65-85 years) of the Longitudinal Aging Study Amsterdam were used. Cox proportional hazard analyses were used to examine whether 25(OH)D and PTH at baseline were associated with overall mortality (with a follow-up of 18 years) and disease-specific mortality (with a follow-up of 13 years). Compared to persons in the reference category of ≥75nmol/L, persons with serum 25(OH)D <25nmol/L (HR 1.46; 95% CI: 1.12-1.91) and 25-49.9nmol/L (HR 1.24; 95% CI: 1.01-1.53) had a significantly higher risk of overall mortality, as well as men with baseline PTH concentrations ≥7pmol/L (HR 2.54 (95% CI: 1.58-4.08)), compared to the reference category of <2.33pmol/L. The relationship of 25(OH)D with overall mortality was partly mediated by PTH. Furthermore, men with PTH concentrations of ≥7pmol/L (HR 3.22; 95% CI: 1.40-7.42) had a higher risk of cardiovascular mortality, compared to the reference category. No significant associations of 25(OH)D or PTH with cancer-related mortality were observed. Both 25(OH)D and PTH should be considered as important health markers

NARCIS 

van Marwijk, Harm W. J.

Observational studies suggest that low concentrations of serum 25-hydroxyvitamin D (25(OH)D) and high concentrations of parathyroid hormone (PTH) are associated with a higher risk of mortality. The aim of this study was to examine whether 25(OH)D and PTH concentrations are independently associated with overall and disease-specific (cardiovascular and cancer-related) mortality in a large, prospective population-based cohort of older adults. Data from 1317 men and women (65–85 years) of the Longitudinal Aging Study Amsterdam were used. Cox proportional hazard analyses were used to examine whether 25(OH)D and PTH at baseline were associated with overall mortality (with a follow-up of 18 years) and disease-specific mortality (with a follow-up of 13 years).    Compared to persons in the reference category of =75 nmol/L, persons with serum 25(OH)D <25 nmol/L (HR 1.46; 95% CI: 1.12–1.91) and 25–49.9 nmol/L (HR 1.24; 95% CI: 1.01–1.53) had a significantly higher risk of overall mortality, as well as men with baseline PTH concentrations =7 pmol/L (HR 2.54 (95% CI: 1.58–4.08)), compared to the reference category of <2.33 pmol/L. The relationship of 25(OH)D with overall mortality was partly mediated by PTH. Furthermore, men with PTH concentrations of =7 pmol/L (HR 3.22; 95% CI: 1.40–7.42) had a higher risk of cardiovascular mortality, compared to the reference category. No significant associations of 25(OH)D or PTH with cancer-related mortality were observed.    Both 25(OH)D and PTH should be considered as important health markers

Jamila El Hilali (16260422)

Elisa J de Koning (16037414)

Adriana J van Ballegooijen (16260425)

Paul Lips (17863)

Evelien Sohl (16260413)

Harm van Marwijk (4663993)

Marjolein Visser (143219)

Natasja M van Schoor (3212757)

Sussex Research Online

Vitamin D, PTH and the risk of overall and disease-specific mortality: results of the Longitudinal Aging Study Amsterdam

http://siba-ese.unisalento.it/index.php/ithaca/article/download/23983/19986

Le nuove frontiere del volo spaziale: Nanotecnologie e Biomedicina

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VU Research Portal

ESE - Salento University Publishing

The University of Manchester - Institutional Repository

Crossref

NARCIS

NARCIS

Sussex Research Online