Darche, Jean-Philippe

Smith, David

Vopat, Bryan

Vopat, Lisa

Zheng, Albert

English

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KANSAS JOURNAL of  M E D I C I N E79Chronic Anterior Knee Pain in a Wrestling Athlete from a Neuroma of the Infrapatellar Branch of the Saphenous NerveJean-Philippe Darche, M.D., Lisa Vopat, M.D., David Smith, M.D., Albert Zheng, M.D., Bryan G. Vopat, M.D.University of Kansas Health System, Department of Orthopedic Surgery and Sports Medicine, Kansas City, KSReceived Sept. 4, 2019; Accepted for publication Dec. 16, 2019; Published online April 17, 2020INTRODUCTIONAnterior knee pain is the most common knee complaint presenting to primary care and orthopaedic offices.1 Many cases are chronic and are not related to a specific precipitating injury or trauma.1,2 Knee pain due to a neuroma is not a common cause of anterior knee pain, and as such is ill defined in medical literature. There have been few case reports identifying painful neuromas from the infrapatellar branch of the saphenous nerve (IBSN) as a cause of chronic pain in patients.3-5 The saphenous nerve is a division of the femoral nerve. It divides into the main saphenous branch and the IBSN. Anatomic models show the IBSN crossing the anterior knee below the patella and dividing into three branches eventually combining to form the patellar plexus. The IBSN is a pure sensory nerve. This nerve may be injured through direct trauma6-9 or surgical procedures such as knee arthroplasties and arthroscopic procedures.3-5,10 In some cases, patients may have pain without significant known trauma.11 Previous case reports have identi-fied this in older patients post-surgically.4,12 This report presents a case of a neuroma causing chronic anterior knee pain in a high school athlete, which to our knowledge is the first reported case in the literature.CASE REPORTA 17-year-old male presented for evaluation of a six-month history of right knee pain. The patient, a high school wrestler, stated that the pain began after he landed directly onto his knee. The pain was located on the anterior medial aspect of the knee, occuring specifically with wres-tling activities. He characterized it as a severe, burning pain only with kneeling, sometimes associated with a shocking and shooting sensation directly over the affected area without radiation of pain. He denied any mechanical symptoms of locking, catching, or giving way and there was no pain with walking, running, or at rest. The patient was unable to wrestle effectively due to pain. Before presenting to our clinic, the patient had been evaluated by two outside orthopaedic surgeons and had already undergone the fol-lowing imaging and procedures: 1. On initial evaluation in 2017, a small extra-articular mass at the medial border of the patella was palpated. A palpable painful fibroma within the prepatellar bursa was presumed to be the source of the pain per the outside physician. Plain film radiographs were unremakable; no further imaging was obtained. The patient under-went prepatellar bursa resection and excision of the tender fibroma. The pathology report demonstrated dense fibrosis and fibroadipose tissue with focal reactive changes and reactive vascular proliferation with mild inflammation. Following the procedure, he completed a course of physical therapy. 2. Three months following the above procedure, there was no improve-ment and patient was evaluated by a second orthopaedic surgeon. An MRI demonstrated mild edema of the subcutaneous tissues anterior to the knee, thought to be postsurgical, as well as a tibial tubercle non-united ossicle that was deemed to be an incidental finding corresponding to his previous history of Osgood-Schlat-ter disease. The MRI was otherwise unremarkable. A diagnostic arthroscopy was performed, identifying a small chondral injury measuring 8 mm x 9 mm along the medial margin of the medial femoral condyle which roughly corresponded to the location of the pain. A chondroplasty was performed, but there was no improve-ment of the pain after 10 weeks. The patient presented to our clinic seeking a third opinion for his knee pain. At the initial visit, a diagnostic supra-patellar, landmark-guided intra-articular injection with 4 ml lidocaine and 3 ml ropivacaine was performed. The patient did not obtain any relief from the injection, thus suggesting an extra-articular cause of his pain unrelated to the chondral lesion that was noted on previous arthroscopy. At that time, patient opted for a trial of conservative management with topical anal-gesics, including 1% topical diclofenac gel and lidocaine patch.At one-month follow-up, the patient reported no change in his pain despite using the topical analgesic. Stardard knee exam was benign without focal tenderness. His pain was reproduced by having him kneel in the exam room. Once the area of pain was localized, physical exam revealed point tenderness and a subtle mass that was located medial to the patella, only noted with the knee flexed past 90 degrees. The palpa-ble, painful, fibrous-like band reproduced the pain. A landmark-guided soft tissue injection was performed at the site of palpable pain using 0.5 ml of 1% lidocaine and 20 mg of triamcinolone. However, this injection did not relieve pain significantly and he was referred to an orthopaedic surgeon for resection of the mass that was thought to be a neuroma or scar tissue (Figure 1). No repeat imaging was ordered, but the recent MRI from 3 months prior to presentation and the arthroscopy proce-dure dictation from 2 months prior were reviewed. The patient underwent a third surgery on his knee, diagnostic arthroscopy, and a plan for resection of the possible neuroma. An inci-sion was made directly over the painful band over the medial femoral condyle and it was dissected to where the band could be palpated. There appeared to be an IBSN neuroma. This was dissected back and resected. At two weeks post-operatively, the patient reported significant improvement in his pain. At the six-week follow-up, his wound was healed and he was able to progressively resume full activities. Since then, he has been able to continue his wrestling career at the collegiate level.This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)KANSAS JOURNAL of  M E D I C I N EFigure 1. The subtle painful fibrous mass at the medial knee was palpable only with the knee in deep flexion.DISCUSSIONThere is a wide differential for chronic anterior knee pain in the student athlete. Common causes of knee pain can be due to patello-femoral pain, ligamentous or meniscal injuries, osteochondral lesions, infrapatellar bursitis, Hoffa syndrome, Osgood-Schlatter disease, patellar or quadriceps tendonitis, or tendinosis.13 It is important to differentiate between intra-articular and extra-articular causes of pain. Knee pain as a result of a neuroma from the IBSN is an extra-articular manifestation. Post-surgical causes of neuromas of the IBSN have been described better than traumatic causes. In a review of two cases from motor vehicle accidents after a dash-board injury, no neuromas were identified, but neurolysis of the IBSN provided immediate resolution of pain.5 Another review of five cases of neuralgia from direct trauma to the anteromedial aspect of the knee that failed conservative treatment, achieved complete resolu-tion of pain from neurolysis of the IBSN.14 In a review of surgical cases, there have been many identified cases related to arthroscopy, anterior cruciate ligament reconstruction with hamstring graft harvesting, and total knee arthroplasties. In respect to patients who had total knee replacements with persistent neuroma-tous pain who had failed conservative therapy, Dellon et al.3 reported significant pain relief in 60 out of 70 patients who proceeded with selective denervation. There are few reports describing neuromas of the IBSN secondary to knee trauma.7-9 To our knowledge, there are no reported cases in a student athlete. Detailed history and careful physical exam may be able to identify a specific area of pain to elucidate pain coming from the IBSN. Trigger point injections may identify the pain as a report from Grabowski et al.15 demonstrated the use of lidgnocaine, providing at least two weeks of pain relief. However, in our patient, the trigger point injection did not result in any subjective relief of the pain at the time of injection of local anesthetic nor in the weeks post-procedure in response to the corticosteroid. Failure of trigger point injection does not rule out pain from the IBSN and that neurolysis or surgical exploration and resec-tion is an appropriate next step. Another consideration would be to order additional imaging such as MRI or musculoskeletal ultrasound if no recent images were available.   CHRONIC ANTERIOR KNEE PAIN IN A WRESTLING          ATHLETE            continued.CONCLUSIONThere have been few case reports identifying painful neuromas from the infrapatellar branch of the saphenous nerve (IBSN) as a cause of chronic anterior knee pain in patients. This case report pre-sented a high school wrestler with a symptomatic IBSN neuroma that was resected successfully and allowed him to return to wrestling.REFERENCES1 Sanchis-Alfonso,V, Dye S. How to deal with anterior knee pain in the active young patient. Sports Health 2017; 9(4):346-351. PMID: 27920260.2 Werner S. Anterior knee pain: An update of physical therapy. Knee Surg Sports Traumatol Arthrosc 2014; 22(10):2286-2294. PMID: 24997734.3 Dellon AL, Mont MA, Krackow KA, Hungerford DS. Partial denervation for persistent neuroma pain after total knee arthroplasty. Clin Orthop Relat Res 1995; (316):145-150. PMID: 7634698.4 Nagai K, Muratsu H, Matsumoto T, Fujibayashi I, Kuroda R, Kurosaka M. Early-onset severe neuromatous pain of the infrapatellar branch of the saphenous nerve after total knee arthroplasty. Asia Pac J Sports Med Arthrosc Rehabil Technol 2014; 1:102-105. 5 Tennent TD, Birch NC, Holmes MJ, Birch R, Goddard NJ. Knee pain and the infrapatellar branch of the saphenous nerve. J R Soc Med 1998; 91(11):573-575. PMID: 10325872.6 Gordon GC. Traumatic prepatellar neuralgia. J Bone Joint Surg Br 1952; 34-B(1):41-44. PMID : 12999868. 7 Harris JD, Fazalare JJ, Griesser MJ, Flanigan DC. Infrapatellar branch of saphenous neurectomy for painful neuroma: A case report. Am J Orthop (Belle Mead NJ) 2012; 41(1):37-40. PMID: 22389894.8 Ikpeme JO, Gray C. Traumatic prepatellar neuralgia. Injury 1995; 26(4):225-229. PMID: 7649620.9 Pendergrass TL, Moore JH. Saphenous neuropathy following medial knee trauma. J Orthop Sports Phys Ther 2004; 34(6):328-334. PMID: 15233394.10 Velickovic M, Ballhause TM. Saphenous neuralgia of the knee. J Ortho Rehab Surg 2017; 1(1):15-18.11 Hosahalli G, Sierakowski A, Venkatramani H, Sabapathy SR. Entrapment neuropathy of the infrapatellar branch of the saphenous nerve: Treated by partial division of sartorius. Indian J Orthop 2017; 51(4):474-476.PMID: 28790478.12 Xiang Y, Li Z, Yu P, Zheng Z, Feng B, Weng X. Neuroma of the infrapatel-lar branch of the saphenous nerve following total knee arthroplasty: A case report. BMC Musculoskelet Disord 2019; 20(1):536. PMID: 31722713.13 Trescot A, Brown MN, Karl HW. Infrapatellar saphenous neuralgia - diagnosis and treatment. Pain Physician 2013; 16(3):E315-324. PMID: 23703431.14 Lippitt AB. Neuropathy of the saphenous nerve as a cause of knee pain. Bull Hosp Jt Dis 1993; 52(2):31-33. PMID: 8443553.15 Grabowski R, Gobbi A, Zabierek S, Domzalski ME. Nonspecific chronic anteromedial knee pain neuroma as a cause of infrapatellar pain syndrome: Case study and literature review. Orthop J Sports Med 2018; 6(1):2325967117751042. PMID: 29404377.Keywords: infrapatellar branch of saphenous nerve, anteromedial knee pain, infrapatellar neuroma, infrapatellar pain syndrome80

Chronic Anterior Knee Pain in a Wrestling Athlete from a Neuroma of the Infrapatellar Branch of the Saphenous Nerve

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Chronic Anterior Knee Pain in a Wrestling Athlete from a Neuroma of the Infrapatellar Branch of the Saphenous Nerve

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