Despite the steady increase in the number of studies focusing on the development of
tissue engineered constructs, solutions delivered to the clinic are still limited. Specifically,
the lack of mature and functional vasculature greatly limits the size and complexity of
vascular scaffold models. If tissue engineering aims to replace large portions of tissue
with the intention of repairing significant defects, a more thorough understanding of the
mechanisms and players regulating the angiogenic process is required in the field. This
review will present the current material and technological advancements addressing the
imperfect formation of mature blood vessels within tissue engineered structures