Ballard, C.

Briel, R.

Gholkar, A.

Harvey, G.T.

Hughes, J.

Ince, P.

McKeith, I.G.

O'Brien, J.T.

Perry, R.H.

Scheltens, P.

NARCIS 

Magnetic resonance imaging differences between dementia with Lewy bodies and Alzheimer's disease; a pilot study

Background. Temporal lobe atrophy on magnetic resonance
 imaging (MRI) has been suggested as 
a specific diagnostic marker for Alzheimer's disease (AD). No previous
 comparison with dementia 
with Lewy bodies (DLB) has been reported.Method. T1-weighted MRI scans were performed on 11 subjects
 with AD (nine with 
NINCDS/ADRDA probable AD and two with neuropathologically proven AD)
 and nine subjects 
with DLB (four with probable DLB diagnosed by clinical criteria and five
 with neuropathologically 
proven DLB). Groups were matched for age, duration of illness and cognitive
 test score. Two raters, 
blind to diagnosis and neuropathological findings, measured the volumes
 of the frontal lobes, 
temporal lobes, hippocampi, parahippocampal gyri, amygdalae, and caudate
 nuclei using a 
computerized volumetric analysis system. Scans were also rated for medial
 temporal atrophy on a 
four-point scale by an experienced rater.Results. AD subjects had significantly smaller left temporal
 lobes and parahippocampal gyri than 
those with DLB. Medial temporal atrophy was present in 9/11 AD cases
 (82%) and absent in 6/9 
(67%) of DLB cases. Two neuropathologically confirmed cases of DLB had
 severe medial temporal 
atrophy; both had concurrent AD-type pathology in the temporal lobe (Braak
 stage 4).Conclusions. This pilot study supports the hypothesis that
 a greater burden of pathology centres on 
the temporal lobes in AD compared with DLB, except in DLB cases with concurrent
 Alzheimer 
pathology. A larger study is needed to confirm these findings and to determine
 whether MRI has 
a role in assisting with the clinical differentiation between DLB and AD.</jats:p

G. T. HARVEY

J. HUGHES

I. G. McKEITH

R. BRIEL

C. BALLARD

A. GHOLKAR

P. SCHELTENS

R. H. PERRY

P. INCE

J. T. O'BRIEN

Crossref

Psychological Medicine

Magnetic resonance imaging differences between 
dementia with Lewy bodies and Alzheimer's disease: 
a pilot study

DSpace at VU

Magnetic resonance imaging differences between dementia with Lewy bodies and Alzheimer's disease; a pilot study

Abstract

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DSpace at VU