Beneficial Effect of the Flavonoid Luteolin on Neuroinflammation

Abstract

128 p.Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2009.Finally, given these potent anti-inflammatory properties of luteolin, as well as the inverse relationship between flavonoid intake and cognitive decline in older persons and aged animals reported by others, we explored whether dietary supplementation of luteolin can ameliorate age-related deficits in spatial working memory and reduce inflammatory molecules in aged brain. Adult and aged mice were provided control or luteolin supplemented diet for four weeks. Dietary supplementation of luteolin attenuated the age-related spatial working memory deficits along with alleviating hippocampal IL-1beta and major histocompatibility complex (MHC) class II mRNA expression in aged mice. Collectively, these studies showed that luteolin might be a promising agent for preventing neuroinflammation and neuronal cell death mediated by activated microglia and consequently, attenuating age-associated cognitive decline.U of I OnlyRestricted to the U of I community idenfinitely during batch ingest of legacy ETD