A series of novel homopiperazine derivatives were synthesized and characterized using 1H NMR, LC MS, IR and elemental analysis data. These novel molecules were evaluated for their antiproliferative activity against Reh, leukemia cells using trypan blue and MTT assays. All the molecules showed cytotoxicity with IC50 values between 50-100 μM as calculated by trypan blue assay and greater than 100 μM as calculated by MTT assay. Compound 6b with 3,5-dinitro substituents on phenyl ring of the aryl carboxamide moiety attached to homopiperazine ring showed good activity with IC50 value of 41 μM
