We describe an agents-based contractual workflow paradigm for Self-organization and autonomy in computational networks. The agent-based paradigm can be interpreted as the outcome arising out of deterministic, nondeterministic or stochastic interaction among a set of agents that includes the environment. These interactions are like chemical reactions and result in self-organization. Since the reaction rules are inherently parallel, any number of actions can be performed cooperatively or competitively among the subsets of elements, so that the agents carry out the required actions. Also we describe the application of this paradigm in finding short duration paths, chemical- patent mining, and in cloud computing services
