New synthetic approach to a [1.1. 6] metapara cyclophane derivative via Suzuki-Miyaura cross-coupling and ring-closing metathesis

Abstract

The synthesis of a [1.1.6] metapara cyclophane derivative, 1,5(1,4),3(1,3)-tribenzenacycloundecaphan-8-ene-6,11-dione, has been achieved via the Suzuki-Miyaura cross-coupling of α, α'-dibromo-m-xylene with an arylboronic acid derivative followed by an allylation and ring-closing metathesis reaction sequence