Synthetic studies towards the nor-triterpene pfaffic acid: synthesis of DEF ring fragment via tandem radical cyclization rearrangement reactions

Abstract

A tandem 5-exo-trig-vinyl-3-exo-radical cyclization-rearrangement reaction and its allylic radical version was developed (8 and 15 to 9 and 16 respectively) for the synthesis of DEF ring system of the nor-tritepene Pfaffic acid 1