Sea surface salinity (SSS) observations from NASA’s satellite missions, Aquarius/SAC-D and Soil Moisture Active Passive (SMAP), are used to describe spatial patterns of the seasonal cycle, as well as intraseasonal and interannual variability, in the eastern tropical Pacific, the location of the second Salinity Processes in the Upper-ocean Regional Study (SPURS-2) field experiment. The results indicate that the distribution of SSS variance is highly inhomogeneous in both space and time. The seasonal signal is largest in the core of the Eastern Pacific Fresh Pool and in the Gulf of Panama. The interannual signal is highest in a relatively narrow zonal band along approximately 5°N, while the intraseasonal signal appears to be a dominant mode of variability in the zonally stretched near-equatorial region. Located right in the middle of a hotspot of high SSS variance, the SPURS-2 site appears to be at the crossroads of many different processes that shape the distribution of SSS in the eastern tropical Pacific and beyond