The purpose of this study was to examine the relationship among plasma levels of prostaglandin E2 (PGE2), leukotriene B4 (LTB4), creatine kinase (CK), lactic acid (LA), and delayed-onset muscle soreness (DOMS) after an acute weight lifting bout involving eccentric contractions in order to determine if PGE2 and/or LTB4 contribute to DOMS. Fourteen college males participated in this study. Nine subjects were randomly assigned to a group which performed a weight lifting bout involving the major muscle groups of the body. Five subjects served as non-exercising controls. Two weeks prior to the weight lifting session both groups were tested for their one-repetition maximum (1RM) on the exercises used in the workout. Two weeks after 1RM testing, subjects in the treatment group performed three sets of each exercise at an intensity of 70% of their 1RM to volitional failure. Venous blood samples and ratings of perceived muscle soreness were obtained before the workout, immediately after the workout, and every 24 hours after the workout for five days. Venous blood samples and ratings of perceived muscle soreness were obtained for the control group every 24 hours for six days
