The Masters in Innovation, Creativity and Leadership (the MICL) is an innovative, radically interdisciplinary and highly successful programme that is offered as part of the portfolio of Management Masters courses at Cass Business School in the UK. In this paper, we argue that while the world is increasingly Volatile, Uncertain, Complex and Ambiguous (VUCA), educational responses to this have been surprisingly limited. We note the parallel development of interest in interdisciplinary activity, particularly in relation to higher education, and then describe the MICL as an interdisciplinary management education programme developed against the background of an increasingly VUCA world. We describe the aims and structure of the MICL programme, as well as some of the methods employed to assist staff and students with adopting our interdisciplinary approach. Finally, we present some quantitative data on outcomes for students after completing the programme, as well as some qualitative data relating to the first cohort of students, that lead us to believe that the MICL programme provides a strong foundation on the basis of which students can survive and thrive in a world of increasingly dramatic change and complexity