We propose a strategy for quantitative photoacoustic mapping of chromophore
concentrations that can be performed purely experimentally. We exploit the
possibility of acousto-optic modulation using focused ultrasound, and the
principle that photons follow trajectories through a turbid medium in two
directions with equal probability. A theory is presented that expresses the
local absorption coefficient inside a medium in terms of noninvasively measured
quantities and experimental parameters. Proof of the validity of the theory is
given with Monte Carlo simulations.Comment: 14 pages, 5 figure

A. Hussain

Bauer

Bratchenia

E. Hondebrink

Gross

K. Daoudi

Laufer

Lesaffre

Rajian

Rosenthal

Selfridge

W. Steenbergen

Wang

Yuan

Zemp

Optics Express

English

arXiv

Crossref

Correcting photoacoustic signals for fluence variations using acousto-optic modulation

We present a theoretical concept which may lead to quantitative photoacoustic mapping of chromophore concentrations. The approach supposes a technique capable of tagging light in a well-defined tagging volume at a specific location deep in the medium. We derive a formula that expresses the local absorption coefficient inside a medium in terms of noninvasively measured quantities and experimental parameters and we validate the theory using Monte Carlo simulations. Furthermore, we performed an experiment to basically validate the concept as a strategy to correct for fluence variations in photoacoustics. In the experiment we exploit the possibility of acousto-optic modulation, using focused ultrasound, to tag photons. Results show that the variation in photoacoustic signals of absorbing insertions embedded at different depths in a phantom, caused by fluence variations of more than one order of magnitude, can be corrected for to an accuracy of 5

Daoudi, Khalid

Hussain, Altaf

Hondebrink, Erwin

Steenbergen, Wiendelt

University of Twente Research Information

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