Carvalho, J

Patey, O

Thilaganathan, B

St George's Online Research Archive

CONTROL ID: 2514873ABSTRACT FINAL ID: OC02.03TITLE: Persistent alteration in myocardial deformation and cardiac geometry and function in growth restricted anddiabetic pregnancies from term fetus to neonateAUTHORS (FIRST NAME, LAST NAME): Olga Patey1, 2, Julene S. Carvalho2, 3, Basky Thilaganathan1, 3INSTITUTIONS (ALL): 1. St George\'s Hospital Medical School, University of London, London, United Kingdom.2. Brompton Centre for Fetal Cardiology, Royal Brompton Hospital, London, United Kingdom.3. Fetal Medicine Unit, St George\'s Hospital, London, United Kingdom.ABSTRACT BODY: Objectives: To evaluate fetal and neonatal ventricular geometry, myocardial deformation and cardiac function innormal, small for gestational age (SGA), and gestational diabetes (GDM) pregnancies at term.Methods: Prospective study of 107 pregnant women at term included three patient groups: normally grown (n=54),SGA (n=33) and GDM fetuses (n=20). Conventional echo, spectral tissue Doppler and 2D speckle tracking imaging(STI) assessing ventricular geometry, all aspects of myocardial deformation and systolic/diastolic function wereperformed few days before the onset of labor and within hours of birth. All cardiac indices were normalized byventricular length.Results: Compared to the normal group, SGA and GDM fetuses demonstrated a significant (p<0.001 for all) alterationin ventricular geometry (RV sphericity index: 1.85 vs. 1.68 vs. 1.51; LV sphericity index: 2.05 vs. 1.87 vs. 1.90,respectively) with corresponding differences in myocardial deformation (LV longitudinal strain rate: -1.9 /s vs. -1.8 /svs. -2.1 /s; LV basal circumferential strain rate: -2.4 /s vs. -2.0 /s vs. -3.0 /s; LV basal radial strain rate: 2.2 /s vs. 1.9 /svs. 2.6 /s; LV torsion: 2.5 deg/cm vs. 1.9 deg/cm vs. 4.7 deg/cm, respectively) as well as cardiac function (RV S’: 5.8cm/s vs. 6.0 cm/s vs. 7.0 cm/s; IVS E’/A’: 0.71 vs. 0.60 vs. 0.60, respectively). All echo indices remained significantlyaltered in SGA and GDM newborns compared to normal neonates.Conclusions: Term SGA and GDM fetuses exhibit altered cardiac indices indicative of myocardial and chamberdysfunction as a consequence of an adverse intrauterine environment with evidence of persistence of geometric andfunctional alterations in cardiac parameters after birth.Additional details  KEYWORDS: Fetal cardiac function, Echocardiography, Diabetes, Intrauterine growth restriction. (no table selected)(No Image Selected)

OC02.03: Persistent alteration in myocardial deformation and cardiac geometry and function in growth restricted and diabetic pregnancies from term fetus to neonate

OC02.03: Persistent alteration in myocardial deformation and cardiac geometry and function in growth restricted and diabetic pregnancies from term fetus to neonate

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