Frizzled receptors are the mediators of the wnt canonical and non-canonical pathways, which play fundamental roles in cell
differentiation and organism development. A large body of work indicates that dysregulation of wnt signalling is a feature of
oncogenic transformation, but most of the studies published so far focus on the assessment of the consequences of aberrations of
the canonical pathway in human cancer. In this review, we discuss the emerging role of the wnt non-canonical pathway regulated
by frizzled receptor 6 (Fzd6) in the pathogenesis of different types of human malignancies. The function played by Fzd6 in the
physiology of normal and cancer cells has been highlighted in the view that an increased knowledge of the signalling pathways
upstream and downstream of this receptor could ultimately result in the identification of new targets for cancer therapy