Regulatory light chains in cardiac development and disease

Abstract

Copyright © 2021 The Author(s). The role of regulatory light chains (RLCs) in cardiac muscle function has been elucidated progressively over the past decade. The RLCs are among the earliest expressed markers during car-diogenesis and persist through adulthood. Failing hearts have shown reduced RLC phosphoryla-tion levels and that restoring baseline levels of RLC phosphorylation is necessary for generating optimal force of muscle contraction. The signalling mechanisms triggering changes in RLC phos-phorylation levels during disease progression remain elusive. Uncovering this information may provide insights for better management of heart failure patients. Given the cardiac chamber-specific expression of RLC isoforms, ventricular RLCs have facilitated the identification of mature ventricular cardiomyocytes, opening up possibilities of regenerative medicine. This review consolidates the standing of RLCs in cardiac development and disease and highlights knowledge gaps and potential therapeutic advancements in targeting RLCs.Singapore Ministry of Education Academic Research Funds (MOE2016-T2-1-106 and 2018-T1001-030).; K.M. funded by Nanyang Technological University research scholarship