An Improved Catalyst for Iodine(I/III)-Catalysed Intermolecular C-H Amination

Abstract

1,2-Diiodobenzene is presented as an efficient catalyst precursor for the intermolecular amination of arenes under homogeneous conditions. N-Troc and N-phthalimido-substituted methoxyamines serve as suitable nitrogen sources providing the corresponding aniline derivatives in up to 99% yield and with up to 66:1 regioselectivity. Key for this successful C-N coupling protocol is the strained m-oxo-bridged conformation of the bisiodine(III) catalyst, which induces unparalleled high reactivity.</p