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research
Template-based structure modeling of protein-protein interactions
Authors
András Szilágyi
Yang Zhang
Publication date
1 January 2014
Publisher
'Elsevier BV'
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PubMed
Abstract
The structure of protein-protein complexes can be constructed by using the known structure of other protein complexes as a template. The complex structure templates are generally detected either by homology-based sequence alignments or, given the structure of monomer components, by structure-based comparisons. Critical improvements have been made in recent years by utilizing interface recognition and by recombining monomer and complex template libraries. Encouraging progress has also been witnessed in genome-wide applications of template-based modeling, with modeling accuracy comparable to high-throughput experimental data. Nevertheless, bottlenecks exist due to the incompleteness of the protein-protein complex structure library and the lack of methods for distant homologous template identification and full-length complex structure refinement. © 2013
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oai:real.mtak.hu:12915
Last time updated on 05/06/2014