In this paper, we present a wireless Multiple Smart Sensor System (MSSS) in conjunction with a smartphone to enable an unobtrusive monitoring of electrocardiogram (ear-lead ECG) integrated with multiple sensor system which includes core body temperature and blood oxygen saturation (SpO2) for ambulatory patients. The proposed behind-the-ear device makes the system desirable to measure ECG data: technically less complex, physically attached to non-hair regions, hence more suitable for long term use, and user friendly as no need to undress the top garment. The proposed smart sensor device is similar to the hearing aid device and is wirelessly connected to a smartphone for physiological data transmission and displaying. This device not only gives access to the core temperature and ECG from the ear, but also the device can be controlled (removed and reapplied) by the patient at any time, thus increasing the usability of personal healthcare applications. A number of combination ECG electrodes, which are based on the area of the electrode and dry/non-dry nature of the surface of the electrodes are tested at various locations near behind the ear. The best ECG electrode is then chosen based on the Signal-to-Noise Ratio (SNR) of the measured ECG signals. These electrodes showed acceptable SNR ratio of ~20 db, which is comparable with existing tradition ECG electrodes. The developed ECG electrode systems is then integrated with commercially available PPG sensor (Amperor pulse oximeter) and core body temperature sensor (MLX90614) using a specialized micro controller (Arduino UNO) and the results monitored using a newly developed smartphone (android) application
