This article discusses general strategies to enable environmental sustainability within the clothing sector, providing a framework for decision makers involved in the development of programs and policies for this sector. It initially revises the environmental impact of the clothing system and determines its key environmental sustainability priorities. The framework involves five evolutionary strategies for enabling sustainable consumption and production: 1) environmental improvement of flows throughout the supply chain; 2) environmental redesign of existing clothes; 3) design of new clothes intrinsically more sustainable; 4) design of cloth-service systems and 5) promoting life styles towards sufficient consumption. The practical implications of each strategy is analysed based on correspondent ex-post-facto case studies identified in Brazil, using data collected through literature review and desktop research