This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.The dynamic gas flow in silica aerogel caused by ambient pressure change is an important factor to influence the thermal conductivity performance. Due to the ultrafine pore size, the flow in the silica aerogel is non-continuum. The direct simulation Monte Carlo method is selected to simulate the transient behavior of gas dynamic flow in nanoporous silica aerogel caused by pressure difference. The influences of pressure ratio and porosity on the unsteady dynamic response and the magnitude of the macroscopic parameters are investigated. The results show that the response processes under different pressure ratio and porosity conditions are similar. The effect of the pressure ratio and porosity are mainly reflected on the magnitude of the macro parameters and response time