This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.A CFD study of bubbles growing in a mini-channel with a diameter of 0.64 mm has been done. Coupled level set and volume of fluid (CLSVOF) method is applied to capture the two phase interface. Geo-reconstruct method is used to re-construct the two-phase interface. A constant velocity inlet boundary with mass flux 335 /2 and a heated boundary wall with constant heat flux (10/2 ) is applied. Both saturated and sub-cooled inlet condition are studied. The growth of bubbles and the transition of flow regime differs each other under these two conditions. Sub-cooling significantly lowers the bubble growth rate. However, it does not affect the heat transfer coefficient at the same level due to its complicated heat transfer mechanism
