Blamire AM

Greally E

Porcari P

Straub V

In this study, we investigated whether diffusion MRI might be a useful method to evaluate differences in the microarchitecture of hindlimb muscles between dystrophic (mdx) and healthy (wt) mice of three groups of age. Mice were investigated at multiple diffusion times and significant differences between the diffusion properties of hindlimb muscles in healthy and diseased mice were found for long diffusion times. High specificity and sensitivity of the method was demonstrated and also confirmed by the preliminary results of the histological assessment, thus suggesting a powerful and straightforward application on humans

In vivo diffusion MR study at 7T of hindlimb muscles in a mouse model of Duchenne muscular dystrophy

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