The programatic ecosystem. The new digital advertising that connects data with people. Programmatic advertising as a process capable of offering advantages for companies, combining audience data management with automation/technology and the human factor is analyzed. The starting premise is that in order to solve the problem of advertising saturation, contents has to be connected with the individuals, one by one and in real time. This work brings together the academic and professional knowledge to analyze the keys to this new form of digital advertising and its main challenges. There is also a focus on synergies between the information sciences and the future of programmatic advertising