The treatment of patients in outpatient healthcare clinics is continually growing as technology improves and recovery benefits are recognized. In this thesis, a simulation framework is developed to model the operational aspects of clinics with the goal of providing a method to understand the impact of clinic design decisions relative to productivity, efficiency, and quality of patient care. The healthcare clinic design simulator (HCD-Sim) is designed to study the dynamic system behavior of clinics and to analyze alternative outpatient healthcare clinic designs. Additionally, the simulation framework is created using a data-driven structure that can represent a large class of outpatient healthcare clinics through the specification of clinic data relative to patient flows, work flows, and resource requirements. To demonstrate capability, the framework is applied to a representative general clinic to analyze capacity and investigate important resources that impact the clinic’s performance. Lastly, the framework is applied to a Bone Marrow Transplant (BMT) clinic application to examine the system and provide design recommendations