The combination of glass vial, elastomeric stopper, and aluminum crimp seal represents one of the principal packaging systems used to package diagnostic reagents, ophthalmic and veterinary medicines, and pharmaceutical products. This work states that elastomeric flat liners are an alternative to traditional stoppers. To confirm this position, several comparative moisture transmission evaluations are conducted to contrast the barrier performance of glued flat liners against stoppers in continuous thread closures on glass vials. After a review of several standard packaging integrity testing methods, this thesis demonstrates the use of coulometric titration as an alternative package system testing methodology. Coulometric titrators are commercially available, and coulometric titration is well established as a precise moisture determination method for determining the micro-moisture contents in both solid and liquid products. The accuracy of coulometric titration technique is well suited for discerning the slight changes in moisture content of hygroscopic products after being packaged in candidate high moisture barrier packaging systems
