Cano C

Galler M

Golding BT

Griffin RJ

Harnor SJ

Newell DR

Rennison T

Reaction of methyl 2,3,4-tri-O-acetyl-1-O-(trichloroacetimidoyl)-alpha-D-glucopyranuronate with 3\u27-deoxy-3\u27-fluorothymidine in the presence of trimethylsilyl trifluoromethanesulfonate gave (2R,3R,4S,5S,6S)2-((( 2R,3S,5R)-3-fluoro-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)-methoxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate, which was hydrolysed to 3\u27-deoxy-3\u27-fluorothymidine-5\u27-glucuronide. Analysis of this reference standard by high performance liquid chromatography enabled the identification of [F-18]3\u27-deoxy-3\u27-fluorothymidine-5\u27-glucuronide in blood samples from six human patients who had been administered [F-18]3\u27-deoxy-3\u27-fluorothymidine

Synthesis of 3 \u27-deoxy-3\u27-fluorothymidine (FLT) 5 \u27-O-glucuronide: a reference standard for imaging studies with [<sup>18</sup>F]FLT

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