Beil W

Fiedler HP

Goodfellow M

Graf E

Jones AL

Nicholson G

Schneider K

Strobele M

Sussmuth RD

Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells

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Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871<sup>+</sup>

Elloxazinones A and B, new aminophenoxazinones from Streptomyces griseus Acta 2871<sup>+</sup>

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