Aalfs CM

Agnarsson BA

Ahn SH

Andrulis IL

Antonenkova N

Antoniou AC

AOCS Study Grp

Arias JI

Askmalm MS

Ausems MGEM

Baglietto L

BCAC-CIMBA

Beesley J

Benitez J

Bermisheva M

Bogdanova N

Bojesen SE

Braaf LM

Brauch H

Brock I

Broeks A

Burwinkel B

Caligo MA

Chang-Claude J

Chen XQ

Chenevix-Trench G

Chu C

Cook J

Cook M

Couch FJ

Cox A

Davidson R

Devilee P

Dieudonne AS

Domchek SM

Dork T

Douglas F

Dunning AM

Easton DF

Eccles D

Eeles R

Elliott G

EMBRACE

Evans DG

Fletcher O

Flyger H

Fredericksen Z

Frost D

Garcia EBG

Gaudet MM

GENICA Network

Gibson L

Giles GG

Gille HJP

Godwin AK

Gold B

Hamann U

Hammet F

Hatse S

Healey S

HEBON

Heikkinen T

Hillemanns P

Hodgson S

Hogervorst FBL

Holland H

Hooning MJ

Hopper JL

Hsiung CN

Humphreys MK

Johnson N

Kang D

Karlsson P

Karstens JH

Kataja V

Kauppinen J

kConFab

Khusnutdinova E

Kirchhoff T

Ko YD

Kosma VM

Lambrechts D

Ligtenberg MJ

Lindblom A

Lindor N

Loman N

Luccarini C

Mannermaa A

Margolin S

McGuffog L

Meindl A

Melin B

Milne RL

Nathanson KL

Nevanlinna H

Noh DY

Nordestgaard BG

Offit K

Oldenburg RA

Oliver CT

Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I-2 = 49.3%; p = &lt;0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95% CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk

Yoo KY

Schurmann P

Olson J

Vachon C

Wang XS

Reed MWR

Schmidt MK

van 't Veer LJ

Peto J

Turnbull C

Seal S

Renwick A

Rahman N

Wu PE

Yu JC

Shen CY

Southey MC

Van Dorpe T

Rogov JI

Prokofieva D

van Asperen CJ

Tollenaar RAEM

Zamora MP

Severi G

Spurdle AB

Wang-Gohrke S

von Wachenfeldt A

Verheus M

Newcastle University E-Prints

English

Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2

Abstract

Similar works

Full text

Available Versions

Newcastle University E-Prints