Aslanidi O

Atia J

Benson AP

Blanks AM

Choi C

Gilbert SH

Goryanin I

Hayes-Gill BR

Holden AV

Li P

Norman JE

Shmygol A

Simpson NAB

Taggart MJ

Tong WC

van den Berg HA

Zhang H

We apply virtual tissue engineering to the full term human uterus with a view to reconstruction of the spatiotemporal patterns of electrical activity of the myometrium that control mechanical activity via intracellular calcium. The three-dimensional geometry of the gravid uterus has been reconstructed from segmented in vivo magnetic resonance imaging as well as ex vivo diffusion tensor magnetic resonance imaging to resolve fine scale tissue architecture. A late-pregnancy uterine smooth muscle cell model is constructed and bursting analysed using continuation algorithms. These cell models are incorporated into partial differential equation models for tissue synchronisation and propagation. The ultimate objective is to develop a quantitative and predictive understanding of the mechanisms that initiate and regulate labour. (C) 2011 Elsevier Ltd. All rights reserved

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Towards a computational reconstruction of the electrodynamics of premature and full term human labour

Towards a computational reconstruction of the electrodynamics of premature and full term human labour

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