Dever TE

Mailliot J

Melnikov S

Micura R

Rigger L

Shin B-S

Yusupov M

Yusupova G

\ua9 2016Eukaryotic translation initiation factor eIF5A promotes protein synthesis by resolving polyproline-induced ribosomal stalling. Here, we report a 3.25-\uc5 resolution crystal structure of eIF5A bound to the yeast 80S ribosome. The structure reveals a previously unseen conformation of an eIF5A–ribosome complex and highlights a possible functional link between conformational changes of the ribosome during protein synthesis and the eIF5A–ribosome association

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Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome

Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome

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