Bolli GB

Bosnyak Z

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Landgraf W

Melas-Melt L

\ua9 2020 The Authors. Diabetes, Obesity and Metabolism published by John Wiley &amp; Sons Ltd.The relationship between baseline fasting C-peptide (FCP) and glucose control was examined in insulin-na\uefve people with type 2 diabetes inadequately controlled with oral antihyperglycaemic drugs commencing basal insulin glargine 300 U/mL (Gla-300) or 100 U/mL (Gla-100) in the absence of sulfonylurea/glinides. Participants with FCP measurement from the EDITION 3 trial (n = 867) were stratified according to baseline FCP (≤0.40, &gt;0.40-1.20, &gt;1.20 nmol/L); 11.0%, 70.9% and 18.1% contributed to each group. Glycaemic control, body weight, insulin dose and hypoglycaemia were determined at 26 weeks. Glycaemic control (HbA1c, FPG) at 26 weeks was similar in each FCP group between insulins. However, end-of-study insulin dose was greater with higher FCP for both insulins. More people with lower baseline FCP experienced hypoglycaemia with both insulins, but with numerically lower incidence for Gla-300 versus Gla-100 across all FCP groups for all definitions (time periods and levels) of hypoglycaemia. This suggests that Gla-300 might be particularly advantageous for people who are at higher risk of hypoglycaemia

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Hypoglycaemia risk with insulin glargine 300 U/mL compared with glargine 100 U/mL across different baseline fasting C-peptide levels in insulin-na\uefve people with type 2 diabetes: A post hoc analysis of the EDITION 3 trial

https://eprint.ncl.ac.uk/fulltext.aspx?url=267101/44FC1623-69AA-49C1-AEE6-2F3509FDED3E.pdf&pub_id=267101

Hypoglycaemia risk with insulin glargine 300 U/mL compared with glargine 100 U/mL across different baseline fasting C-peptide levels in insulin-na\uefve people with type 2 diabetes: A post hoc analysis of the EDITION 3 trial

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